Haife shi a Como, Italiya a cikin 1702 na haihuwa mai daraja. A Spain, inda ya isa yana tsere daga yaƙin Austriya, ya karɓi iko da yawa don karɓar fansho na zuriyar Moctezuma a cikin Royal Cajas na Mexico.
Ya yi tafiya zuwa New Spain a cikin 1736. A tsawon shekaru takwas da ya yi ya sadaukar da kansa don bincika bayyanar budurwar Guadalupe, yana tattara abubuwa masu mahimmanci da hotuna. Yana inganta rawanin ɗaukakar hoton Guadalupan, wanda ke haifar da rashin yarda da hukumomin ƙaura. An kama shi fursuna kuma an cire kayan da aka tara. Watanni bayan haka, bayan an tasa keyarsa zuwa Sifen, sai ya hau wani jirgin ruwa wanda ya fada hannun 'yan fashin da suka yi watsi da shi a Gibraltar.
Tare da manyan ayyuka ya isa Spain kuma ya sadu da mai karɓar Mariano Fernández de Echeverríay Veytia wanda ya sami nasarar sake shi a matsayin Royal Chronicler na Indies, matsayin da Boturini ya ƙi sadaukar da kansa ga rubutu game da tarihin 'yan asalin ƙasar. Kodayake bai taɓa dawo da tarinsa ba, ya rubuta Catalog na Gidan Tarihi na Indiya a kai. Aikinsa asalinsa ne kuma anyi masa rubuce rubuce sosai. Ya mutu a Madrid a ranar da ba ta da tabbas, tsakanin 1750 da 1755.
