An haife shi a Ozumba, Jihar Meziko, a 1737, ya rungumi aikin addini kuma an naɗa shi firist yana ɗan shekara ashirin.
Duk da karatunsa na ilimin falsafa, tun yana ƙarami yana damuwa da ilimi da amfani da ilimin kimiyyar ƙasa, kimiyyar lissafi, lissafi da ilimin taurari. Yana wallafa kyawawan ayyuka akan batutuwan kimiyya a cikin jaridu da mujallu na lokacinsa. Ya sami sanannun duniya kuma an sanya shi abokin tarayya na Kwalejin Kimiyya ta Paris. Yana yawan amfani da lokacinsa wajen gudanar da gwaje-gwajen kimiyya sannan ya tara babban dakin karatu. Ya kasance mai tattara kayan adana kayan tarihi da samfuran shuke-shuke da dabbobi. Binciken Xochicalco. Don yin mubaya'a a gare shi, a cikin 1884 aka kafa Antonio Alzate Scientific Society, wanda a cikin 1935 ya zama National Academy of Sciences. Babban sanannen aikin editan shi ne bayanin kula da Tarihin Tarihin Mexico ta hanyar Jesuit Francisco Javier Clavijero. An ce shi dangi ne mai nisa na Sor Juana Inés de la Cruz. Ya mutu a Mexico City a 1799.
